I tausaga talu ai nei, o suʻesuʻega iBenzylamino acids(Benzylation of Amino Acids) ua tosina mai ai tagata lautele. Benzylamino acid o se metotia faʻapipiʻi vailaʻau, lea e mafai ona ausia suiga faʻatinoga e ala i le faʻaofiina o kulupu benzyl i molelaʻau amino acid, ma e tele avanoa faʻaoga. Amino acids o poloka faʻavae autu ia o polotini, ma o latou meatotino ma fausaga e taua tele i le gaioiga o polotini. E ala i le faʻaofiina o vaega o le benzyl, o le a suia le physicochemical properties o molelaʻau amino acid, ma faʻalauteleina ai lona faʻaogaina i le matata o vailaʻau, mea faasaienisi ma le faʻaogaina o meaola.
I le matata o vailaʻau, o suʻesuʻega i luga o le phenylmethyl amino acid e faʻaaogaina lautele i le faʻaogaina o vailaʻau. O lona gafatia e faʻafeiloaʻi vaega o le benzyl e maua ai mole mole vailaʻau ma se fausaga mautu ma se avanoa e faʻaleleia ai lo latou faʻaogaina. Ole hydrophilicity ma le lipid solubility o molelaʻau vailaʻau e mafai ona fetuunai e ala i le faʻaofiina o kulupu benzyl, ma faʻaleleia atili ai a latou gaioiga faʻafomaʻi ma bioavailability. O lenei mea e maua ai le tele o avanoa mo le atinaʻeina o vailaʻau fou ma faʻalauteleina le faʻafouina ma le atinaʻe i le matata o vailaʻau. E le gata i lea, o le phenylmethylamic acid o loʻo i ai foi le tele o faʻaoga faʻaoga i le matata o mea faasaienisi.
E ala i le faʻatonutonuina o tulaga faʻapipiʻi, mea polymer ma galuega faʻapitoa e mafai ona saunia. O le faʻaofiina o kulupu benzyl e mafai ona faʻafetaui le gaioiga i luga ma mea faʻainisinia o meafaitino, ma faʻaleleia atili ai le faʻatinoga ma le gaioiga o mea. E iai a'afiaga taua mo le atina'eina o matā'upu e pei o mea tau ma'a, fa'ama'i ma masini. E le gata i lea, o le atinaʻeina o le p-benzyl amino acid method e iai foʻi se sao taua i le faʻaogaina o meaola. I le faʻaaogaina o lenei metotia, e mafai ai e tagata suʻesuʻe ona suia tonu le fausaga o molelaʻau amino acid e faʻapipiʻi ai mea faʻapitoa faʻatasi ma galuega faʻapitoa, e pei o vailaʻau vavalo ma mole mole aoga. E maua ai se fa'avae lautele mo kemisi fa'akomepiuta fa'aola ma fa'alauiloa atili le atina'eina o kemisi fa'aola.
I le taimi nei, o se faasologa o mea taua na faia i le suʻesuʻega o le p-phenylmethylamino acid. I le tasi itu, e tusa ai ma metotia faʻapipiʻi, o loʻo faʻatautaia pea e le au suʻesuʻe tulaga faʻaalia ma faiga faʻapipiʻi e faʻaleleia ai le lelei o le tali ma le filifilia. I le isi itu, e tusa ai ma fanua talosaga, o le phenylmethylamino acid method ua faʻaaogaina lautele i suʻesuʻega vailaʻau ma mea faʻasaienisi, ma ua ausia se faasologa o taunuuga taua. I se upu, o le suʻesuʻega ma le faʻaogaina o le p-phenylmethylamino acid o le a faia ai se sao lelei i le atinaʻeina o saienisi ma tekinolosi. O le faʻaogaina fou o lenei metotia e le gata ina faʻalauteleina le atinaʻeina o le vailaʻau faʻafomaʻi, ae o loʻo aumaia ai foʻi mea fou fou ma faʻafouga i le matata o mea faʻasaienisi ma faʻasologa o meaola. E talitonuina o taumafaiga a le tele o tagata suʻesuʻe, o le faʻaaogaina o le phenylmethylamino acid o le a faʻaalia ai se avanoa lautele i le lumanaʻi.
Taimi meli: Aukuso-10-2023
